The nucleus pulposus and annulus fibrosus have poor blood supply and limited regenerative capacity on their own
Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide
When is a B12 shot worthwhile
Then, the dose might change based on how you react and other factors
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